Supplementary MaterialsSupplementary info 41598_2019_53234_MOESM1_ESM

Supplementary MaterialsSupplementary info 41598_2019_53234_MOESM1_ESM. (TLR) ligands induced TNF creation and TXNIP down-regulation, suggesting that damage-associated molecular patterns (DAMPs), such as endogenous TLR ligands, released during DGC play a role in DGC-induced TXNIP down-regulation. Finally, we demonstrate that TNF-induced TXNIP down-regulation…