We observed somewhat increased manifestation of CD274/PD-L1 on LCs and Langerin+ dDCs in response to both adjuvants, whereas CD273/PD-L2 and CD275/ICOSL remained unchanged (Supplementary Fig S3A and B)

We observed somewhat increased manifestation of CD274/PD-L1 on LCs and Langerin+ dDCs in response to both adjuvants, whereas CD273/PD-L2 and CD275/ICOSL remained unchanged (Supplementary Fig S3A and B). into C57BL/6 mice. The next day, mice were immunized i.d. into both…

As opposed to the programmed nature of development, it is still a matter of debate whether aging is an adaptive and regulated process, or merely a consequence arising from a stochastic accumulation of harmful events that culminate in a global state of reduced fitness, risk for disease acquisition, and death

As opposed to the programmed nature of development, it is still a matter of debate whether aging is an adaptive and regulated process, or merely a consequence arising from a stochastic accumulation of harmful events that culminate in a global…