Data Availability StatementRC-seq FASTQ files are available from the European Nucleotide Archive (ENA) under the identifier PRJEB1785. Despite sequencing L1 integration sites at up to 250 depth by RC-seq, we found no tumour-specific, endonuclease-dependent L1 insertions. Whole genome sequencing analysis…
Eukaryotic initiation factor 2B (eIF2B) a five subunit guanine nucleotide exchange
Eukaryotic initiation factor 2B (eIF2B) a five subunit guanine nucleotide exchange factor (GEF) plays a key role in the regulation of mRNA translation. expression was accompanied by reductions in GEF activity and global rates of protein synthesis. Moreover repressed eIF2Bε…