Supplementary Materials Supplemental Material supp_209_1_111__index. a lysosomal phosphorylated polyubiquitin chain recruited

Supplementary Materials Supplemental Material supp_209_1_111__index. a lysosomal phosphorylated polyubiquitin chain recruited phosphomimetic Parkin to the lysosome. A cellular ubiquitin replacement system confirmed that ubiquitin phosphorylation is indeed essential for Parkin translocation. Furthermore, physical interactions between phosphomimetic Parkin and phosphorylated polyubiquitin…