T helper (Th) 2-reliant type 2 immune system pathways have already been recognized as a significant driver for the introduction of fibrosis. fibrosis. These results, alongside the quickly growing commercialization and creation of CNTs and CNT-containing components lately, have got…
Supplementary Materials Supplemental Material supp_209_1_111__index. a lysosomal phosphorylated polyubiquitin chain recruited
Supplementary Materials Supplemental Material supp_209_1_111__index. a lysosomal phosphorylated polyubiquitin chain recruited phosphomimetic Parkin to the lysosome. A cellular ubiquitin replacement system confirmed that ubiquitin phosphorylation is indeed essential for Parkin translocation. Furthermore, physical interactions between phosphomimetic Parkin and phosphorylated polyubiquitin…