The PI3K/mammalian Target of Rapamycin (mTOR) pathway is frequently aberrantly activated in rhabdomyosarcoma (RMS) and represents a promising therapeutic target. PI3K inhibitor NVP-BKM120 and Akt inhibitor synergize with ABT-737 to result in apoptosis, whereas no cooperativity is available for the…
The (loss-of-function alleles failed to promote DCC degradation. oligomerization and binding
The (loss-of-function alleles failed to promote DCC degradation. oligomerization and binding to target proteins such as DCC. The development of the R7 photoreceptor cell in the compound eye has been highly amenable to study and many genes that designate its…