Open in another window We previously reported the look of spirooxindoles

Open in another window We previously reported the look of spirooxindoles with two identical substituents on the carbon-2 from the pyrrolidine core seeing that potent MDM2 inhibitors. 2.04C1.68 (m, 5H), 1.52 (q, 1H, = 14.6 Hz), 1.31C1.09 (m, 2H); ESI-MS 476.25 (M + 1)+. (3= 7.2 Hz), 7.49 (dd, 1H, = 2.2, 8.1 Hz), 7.27 (t, 1H, = 7.3 Hz), 7.13C7.03 (m, 2H), 6.68 (s, 1H), 4.79 (d, 1H, = 9.6 Hz), 4.64 88441-15-0 supplier (d, 1H, = 9.6 Hz), 3.70 (t, 1H, = 13.1 Hz), 3.44C3.18 (m, 3H), 2.77 (d, 3H, = 4.3 Hz), 2.39 (d, 1H, = 14.5 Hz), 2.10C1.88 (m, 2H), 1.50C1.26 (m, 1H). ESI-MS 477.17 (M + 1)+. (3= 7.3 Hz), 7.47 (dd, 1H, = 2.1, 8.2 Hz), 7.25 (t, 1H, = 7.5 Hz), 88441-15-0 supplier 7.12C7.01 (m, 2H), 6.77 (d, 1H, = 1.6 Hz), 4.76 88441-15-0 supplier (d, 1H, = 9.5 Hz), 4.62 (d, 1H, = 9.5 Hz), 3.75 (t, 1H, = 12.5 Hz), 3.52C3.40 (m, 2H), 3.24C3.12 (m, 1H), 2.86 (s, 3H), 2.76 (d, 3H, = 4.0 Hz), 2.40 (d, 1H, = 14.4 Hz), 2.12C1.86 (m, 2H), 1.54C1.34 (m, 1H); ESI-MS 491.08 (M + 1)+. (3= 7.8 Hz), 7.47 (dd, 1H, = 2.6, 8.2 Hz), 7.31 (t, 1H, = 8.3 Hz), 7.15C7.04 (m, 2H), 6.75 (d, 1H, = 1.7 Hz), 4.77 (d, 1H, = 10.1 Hz), 4.61 (d, 0.5H, = 16.4 Hz, rotamer), 4.43 (d, 0.5H, = 11.9 Hz, rotamer), 4.00 (d, 0.5H, = 13.1 Hz, rotamer), 3.85 (d, 0.5H, = 12.6 Hz, rotamer), 3.81C3.68 (m, 1H), 2.76 (s, 3H), 2.56C2.40 (m, 1H), 2.16C1.76 (m, 5H), 1.45C1.11 (m, 2H); ESI-MS 519.17 (M + 1)+. (3= 7.9 Hz 1H), 7.63 (ddd, 1H, = 1.5, 6.5, 7.9 Hz), 7.51 (dd, 1H, = 2.3, 8.2 Hz), 7.37 (t, 1H, = 8.3 Hz), 7.19C7.07 (m, 2H), 6.80 (d, 1H, = 1.9 Hz), 5.02 (d, 1H, = 10.8 Hz), 4.74 (d, 1H, = 10.8 Hz), 4.11C3.93 (m, 2H), 3.87 (dd, 1H, = 3.9, 12.4 Hz), 3.69C3.55 (m, 2H), 3.50C3.38 (m, 1H), 2.62 (d, 1H, = 13.2 Hz), 2.26C2.12 (m, 1H), 2.04C1.73 (m, 4H), 1.70C1.17 (m, 5H), 1.08 (ddd, 1H, = 3.5, 12.7, 24.0 Hz); ESI-MS 562.67 (M + 1)+. (3= 8.1 Hz), 7.62 (t, 1H, = 7.2 SLAMF7 Hz), 7.49 (dd, 1H, = 2.3, 8.2 Hz), 7.33 (t, 1H, = 8.3 Hz), 7.16C7.05 (m, 2H), 6.78 (d, 1H, = 1.9 Hz), 4.77 (d, 1H, = 10.3 Hz), 3.70C3.41 (m, 2H), 2.74C1.64 (m, 11H), 1.48C1.21 (m, 4H), 1.18C1.02 (m, 1H); ESI-MS 596.75 (M + 1)+. (3= 1.9, 8.2 Hz), 7.52 (ddd, 1H, = 1.5, 6.4, 7.9 Hz), 7.39 (ddd, 1H, = 1.5, 7.3, 8.6 Hz), 7.18C7C11 (m, 2H), 6.89 (d, 1H, = 1.9 Hz), 4.92 (d, 1H, = 10.9 Hz), 4.46 (d, 1H, = 10.9 Hz), 3.68C3.58 (m, 1H), 3.50C3.39 (m, 1H), 2.78 (dd, 2H, = 14.5, 39.1 Hz), 2.37 (d, 1H, = 14.2 Hz), 1.95C1.76 (m, 3H), 1.69C1.59 (m, 1H), 1.38C1.17 (m, 7H), 88441-15-0 supplier 0.98 (ddd, 1H, = 3.6, 12.9, = 24.3 Hz), 0.54 (s, 3H); ESI-MS 560.25 (M + H)+. (3= 7.9 Hz), 7.48 (dd, 1H, = 1.4, 7.8 Hz), 7.35C7.25 (m, 1H), 7.15C7.04 (m, 2H), 6.78 (d, 1H, = 1.7 Hz), 4.73 (d, 1H, = 9.9 Hz), 3.67C3.57 (m, 1H), 3.52C3.43 (m, 1H), 2.08C1.64 (m, 8H), 1.58C1.42 (m, 2H), 1.41C1.20 (m, 6H), 0.98 (s, 3H), 0.73 (s, 3H); ESI-MS 588.25 (M + H)+. (3= 2.1 Hz), 8.24 (d, 1H, = 1.7 Hz), 7.89 (s, 1H), 7.60 88441-15-0 supplier (d, 1H, = 8.2 Hz), 7.14 (dd, 1H, = 1.8, 8.2 Hz), 6.78 (d, 1H, = 1.8 Hz), 5.10 (d, 1H, = 10.9 Hz), 4.47 (d, 1H, = 10.9 Hz), 3.73C3.57 (m, 1H), 3.50C3.36 (m, 1H), 2.83 (d, 1H, = 12.5 Hz), 2.17 (d, 1H, = 14.3 Hz), 2.03C1.70 (m, 8H), 1.70C1.13 (m, 7H), 1.08C0.88 (m, 1H); ESI-MS 543.75 (M + H)+. (3= 6.7 Hz), 7.36C7.27 (m, 1H), 7.11 (t, 1H, = 8.6 Hz), 6.81 (s, 1H).