The levels of brain-derived neurotrophic factor (BDNF) are significantly decreased in

The levels of brain-derived neurotrophic factor (BDNF) are significantly decreased in patients with schizophrenia and correlate with impairments in cognitive function. gender age and estimated intelligence quotient (IQ) and we investigated the differences in decision-making overall performance around the Iowa Gambling Task (IGT) between the schizophrenia patient and control groups. We also compared the IGT scores the serum BDNF levels and the clinical symptoms between Mouse monoclonal to Tag100. Wellcharacterized antibodies against shortsequence epitope Tags are common in the study of protein expression in several different expression systems. Tag100 Tag is an epitope Tag composed of a 12residue peptide, EETARFQPGYRS, derived from the Ctermini of mammalian MAPK/ERK kinases. the groups. The IGT scores of the schizophrenia patients were lower than those of the controls. A negative correlation was detected between the mean net scores around the trials in the final two blocks and the serum BDNF levels (< 0.05). Multiple regression analysis revealed that depressive symptoms and the serum BDNF levels were significantly associated with the mean net scores around the trials in the final two blocks. Based Exatecan mesylate on these results impaired sensitivity to both incentive and punishment is usually associated with depressive symptoms and reduced serum BDNF levels in chronic schizophrenia patients and may be related to their poor overall performance around the IGT. < 0.001) and the block (< 0.001) and a significant group × block conversation (< 0.001). A follow-up impartial < 0.001) and a significant group × deck conversation (< 0.001). Follow-up < 0.05 even after the Bonferroni correction). Within-group comparisons were used to clarify the pattern of overall performance; the controls selected the advantageous decks more frequently [(C + D) ? (A + B)] (= 3.95 < 0.001) than the patients with schizophrenia. Physique 2 Quantity of card choice selected from each deck during the 100-card task. Gambling Task overall performance clinical symptoms and serum BDNF levels No correlation was found between the total scores and mean net scores around the IGT and the PANSS-P PANSS-N or PANSS-T (Table ?(Table3).3). A significant negative correlation was detected between the mean net scores on trials 61-100 and the PANSS-G scores. A significant unfavorable correlation was observed between the imply net scores around the trials in the final two blocks (61-80 and 81-100) and the serum BDNF levels (Table ?(Table3).3). Table ?Table44 shows the multiple regression analysis results for the mean net scores on each block of the trials. Depressive symptoms and the serum BDNF levels were significantly associated with the mean net scores around the trials in the final two blocks. Table 3 Correlation between the Iowa Gambling Task overall performance and serum BDNF estimated IQ and clinical symptoms. Table 4 Multiple regression analysis results for the imply net scores on each block of the trials. Discussion A significant finding in the present study was that the serum BDNF levels and depressive symptoms correlated with decision-making. Several previous studies reported that schizophrenia patients exhibited diminished decision-making abilities compared to healthy individuals (Beninger et al. 2003 Ritter et al. 2004 Lee et al. 2007 Kim et al. 2009 Struglia et al. 2011 To the best of our knowledge this is the first report to provide evidence suggesting that this serum BDNF levels reflect decision-making ability in patients with chronic schizophrenia. A recent meta-analysis revealed that this serum BDNF levels in schizophrenia patients are lower than those in healthy individuals (Green et al. 2011 In addition recent studies have reported an Exatecan mesylate association between poor overall performance around the IGT and the volume of several lesions in the hippocampus (Bonatti et al. 2009 Labudda et Exatecan mesylate al. 2009 Yamano et al. 2011 The expression level of BDNF is normally high in the hippocampus. Taking these findings into account diminished serum BDNF level in schizophrenia patients may reflect their poor decision-making overall performance. In short serum BDNF may serve as a biomarker of decision-making ability in schizophrenia patients. Wilder et al. reported that schizophrenia patients often selected the decks corresponding to infrequent and Exatecan mesylate high-magnitude punishments (Wilder et al. 1998 Another study confirmed the finding that schizophrenia patients performed poorly compared to healthy individuals and often selected cards from your deck corresponding to high-magnitude punishments (Shurman et al. 2005 In the present study the schizophrenia patients selected from.